Research
We explore the frontiers of protein biology through integrated computational and experimental approaches — from molecular dynamics simulations to bench-top biochemistry.
Peroxiredoxin & Redox Biology
How do cells defend against oxidative stress, and what role does Peroxiredoxin-6 play?
Investigating the structural and functional aspects of Peroxiredoxin-6, revealing its resistance to stress conditions and its role as a guardian in lung pathophysiology. Our work explores hyperoxidation-induced conformational transitions, pH-dependent structural stability, and the structural basis of the peroxidase catalytic cycle — enhancing understanding of antioxidant mechanisms in cellular protection.
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Proteopathies & Neurodegeneration
What drives toxic protein aggregation in neurodegenerative diseases?
Contributing to the literature on protein aggregation diseases, including novel perspectives on alpha-synuclein associated proteopathy and strategies for treatment. Our research explores protein misfolding, aggregation dynamics, macromolecular crowding effects, and the role of small cellular solutes on cellular antioxidant systems — advancing knowledge in neurodegenerative disorders.
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SARS-CoV-2 & Cardiac Amyloidosis
Can SARS-CoV-2 proteins trigger cardiac amyloidosis?
Pioneering research on the relationship between SARS-CoV-2 infection and cardiac amyloidosis. Our work investigates how SARS-CoV-2 surface and secretory proteins interact with amyloidogenic proteins responsible for cardiac amyloidosis, highlighting protein interactions and their clinical implications for cardiovascular health in collaboration with international partners.
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Millet Protein & Food Science
Are millet seed proteins the answer to sustainable global nutrition?
Comprehensive research on foxtail millet (Setaria italica), emphasizing its nutritional potential and applications in food science. Our studies focus on the preparation and characterization of protein concentrates from millet seeds, promoting the use of millet as a sustainable and nutritious protein source for global food security.
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Drug Discovery & Antimicrobial Resistance
How can we identify new drug targets against multidrug-resistant bacteria?
Active research in understanding antibiotic resistance mechanisms in K. pneumoniae and developing novel drug targets for resistant bacteria. Collaborating with CSIR-IMTECH Chandigarh, our team integrates computational approaches with experimental validation to identify therapeutic strategies against multidrug-resistant pathogens.
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Computational & Structural Biology
Can molecular simulations predict disease-causing protein mutations?
Leveraging bioinformatics, molecular docking, and in-silico approaches to study deleterious nucleotide polymorphisms, predict their impact on protein structure and function, and identify novel drug targets. Our computational work spans genome and transcriptome data analysis, MDM2 polymorphism studies in cancer resistance, and protein dynamics simulations.
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Interested in Collaborating?
We welcome national and international research partnerships.
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