Dr. Rimpy Kaur Chowhan

How do proteins misfold, and how can we stop it?

Investigating protein dynamics, redox biology, and neurodegeneration. Guiding the development of agentic AI to accelerate therapeutic discovery and actively mentoring student led startup.

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Publications

Years Research

Students Mentored

What We Study

Questions Driving Our Research

How do cells defend against oxidative damage?

Peroxiredoxin & Redox Biology

Investigating the structural and functional aspects of Peroxiredoxin-6, revealing its resistance to stress conditions and its role as a guardian in lung pathophysiology. Our work explores hyperoxidation-induced conformational transitions, pH-dependent structural stability, and the structural basis of the peroxidase catalytic cycle — enhancing understanding of antioxidant mechanisms in cellular protection.

Why do proteins misfold and cause disease?

Proteopathies & Neurodegeneration

Contributing to the literature on protein aggregation diseases, including novel perspectives on alpha-synuclein associated proteopathy and strategies for treatment. Our research explores protein misfolding, aggregation dynamics, macromolecular crowding effects, and the role of small cellular solutes on cellular antioxidant systems — advancing knowledge in neurodegenerative disorders.

How does COVID-19 damage the heart?

SARS-CoV-2 & Cardiac Amyloidosis

Pioneering research on the relationship between SARS-CoV-2 infection and cardiac amyloidosis. Our work investigates how SARS-CoV-2 surface and secretory proteins interact with amyloidogenic proteins responsible for cardiac amyloidosis, highlighting protein interactions and their clinical implications for cardiovascular health in collaboration with international partners.

Can ancient grains solve modern nutrition?

Millet Protein & Food Science

Comprehensive research on foxtail millet (Setaria italica), emphasizing its nutritional potential and applications in food science. Our studies focus on the preparation and characterization of protein concentrates from millet seeds, promoting the use of millet as a sustainable and nutritious protein source for global food security.

How do we fight antibiotic resistance?

Drug Discovery & Antimicrobial Resistance

Active research in understanding antibiotic resistance mechanisms in K. pneumoniae and developing novel drug targets for resistant bacteria. Collaborating with CSIR-IMTECH Chandigarh, our team integrates computational approaches with experimental validation to identify therapeutic strategies against multidrug-resistant pathogens.

Can computation predict protein behavior?

Computational & Structural Biology

Leveraging bioinformatics, molecular docking, and in-silico approaches to study deleterious nucleotide polymorphisms, predict their impact on protein structure and function, and identify novel drug targets. Our computational work spans genome and transcriptome data analysis, MDM2 polymorphism studies in cancer resistance, and protein dynamics simulations.

Latest Work

Selected Publications

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2023

Preparation and nutritional characterisation of protein concentrate prepared from foxtail millet (Setaria italica)

Niharika Sachdev, Sangeeta Goomer, Laishram Rajender Kumar Singh, and Rimpy Kaur Chowhan

Food Science and Technology International

DOI Paper

Current Status Of Millet Seed Proteins And Its Applications: A Comprehensive Review

Niharika Sachdev, Sangeeta Goomer, Laishram Rajenderkumar Singh, Vinay Mohan Pathak, Dipesh Aggarwal, and Rimpy Kaur Chowhan

Applied Food Research 3(1), 100288

DOI Paper

2021

pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature

Rimpy Kaur Chowhan, Sunaina Hotumalani, Hamidur Rahaman, and Laishram Rajendrakumar Singh

Scientific Reports (Nature Research) 11, 9657Highlighted Publication

DOI Paper

Peroxiredoxin-6: A Guardian of Lung Pathophysiologies

Anju Kumari, Rimpy Kaur Chowhan, Pushpa Kakchingtabam, et al.

Current Protein and Peptide Science 22(9), 666-674

COVID-19 and cardiovascular disease: Clinical implications of biochemical pathways

Shivani G Varmani*, Rimpy Kaur Chowhan*, Ishani Sharma, and Rajiv Narang (* Equal contribution)

Journal of the Practice of Cardiovascular Sciences 7(2), 97-107

Assistant Professor

Dr. Rimpy Kaur Chowhan

Assistant Professor, University of Delhi

Dr. Rimpy Kaur Chowhan is an Assistant Professor at Acharya Narendra Dev College, University of Delhi. She completed her Ph.D. in Biomedical Science from Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi (2021), supported by prestigious CSIR and ICMR fellowships. Her research spans protein structure & folding dynamics, peroxiredoxin biology, neurodegenerative disorders, SARS-CoV-2 cardiac amyloidosis, millet protein applications, and antimicrobial resistance. With 15+ peer-reviewed publications including papers in Nature's Scientific Reports, she has presented her work at international conferences across India, Austria, and the USA. She is a recipient of multiple international travel awards from DST-SERB and has qualified CSIR-NET (AIR 55) and GATE examinations. Dr. Chowhan is deeply involved in curriculum development under NEP 2020, coordinates the DBT STAR College Scheme, and mentors undergraduate ELITE project students in cutting-edge biomedical research.

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