Peroxiredoxin & Redox Biology

Investigating the structural and functional aspects of Peroxiredoxin-6, revealing its resistance to stress conditions and its role as a guardian in lung pathophysiology. Our work explores hyperoxidation-induced conformational transitions, pH-dependent structural stability, and the structural basis of the peroxidase catalytic cycle — enhancing understanding of antioxidant mechanisms in cellular protection.

Current Investigations

Our laboratory heavily focuses on understanding the molecular underpinnings described above. Through a combination of in-silico predictions and in-vitro experimental validation, we aim to bridge the gap between basic mechanistic understanding and translational therapeutic strategies.